001).Ī topical capsaicin cream decreases postsurgical neuropathic pain and, despite some toxicities, is preferred by patients over a placebo by a three-to-one margin among those expressing a preference. Of the responding patients, 60% chose the capsaicin arm, 18% chose the placebo arm, and 22% chose neither (P =. On completion of the 16-week study period, patients were asked which treatment period was most beneficial. 01) after the first 8 weeks, with an average pain reduction of 53% versus 17%. ![]() The capsaicin cream arm had substantially more pain relief (P =. It has been used to treat nerve pain inside the mouth, for patients with painful sores from cancer therapy. 075, is also used to treat the neuropathic pain of postherpetic neuralgia. Nonetheless, treatment was stopped for patient refusal or toxicity just as often while patients were receiving the placebo as compared with the capsaicin. Capsaicin cream, which comes in two strengths. Treatment evaluation was performed by patient-completed weekly questionnaires.ĭuring the first 8-week study period, the capsaicin-cream arm was associated with substantially more skin burning, skin redness, and coughing (P <. A capsaicin/placebo cream was to be applied to the painful site four times daily. After stratification, patients were to receive 8 weeks of a 0.075% capsaicin cream followed by 8 weeks of an identical-appearing placebo cream, or vice versa. However, these require regular administration and also bear less hazardous but inconvenient disadvantages (e.g., potential contamination of hands during application or clothes afterwards). Ninety-nine assessable patients with postsurgical neuropathic pain were entered onto this study. In localized neuropathic pain states, topically applicable lidocaine and ketamine, as well as low-dose capsaicin cream (0.0250.075), are in use. Based on evidence that capsaicin, the pungent ingredient in hot chili peppers, might be useful for treating neuropathic pain, we developed the present clinical trial. In localized neuropathic pain states, topically applicable lidocaine and ketamine, as well as low-dose capsaicin cream (0.0250.075), are in use. Qutenza patch is also used to treat nerve pain caused by diabetic peripheral neuropathy of the feet. Capsaicin is also used to help relieve minor pain associated with rheumatoid arthritis or muscle sprains and strains. ![]() A minority of cancer survivors develops long-term postsurgical neuropathic pain. Descriptions Capsaicin is used to help relieve a certain type of pain known as neuralgia (shooting or burning pain in the nerves).
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